RAD51 and Breast Cancer Susceptibility: No Evidence for Rare Variant Association in the Breast Cancer Family Registry Study
Identifieur interne : 005506 ( Main/Exploration ); précédent : 005505; suivant : 005507RAD51 and Breast Cancer Susceptibility: No Evidence for Rare Variant Association in the Breast Cancer Family Registry Study
Auteurs : Florence Le Calvez-Kelm [France] ; Javier Oliver [France] ; Francesca Damiola [France] ; Nathalie Forey [France] ; Nivonirina Robinot [France] ; Geoffroy Durand [France] ; Catherine Voegele [France] ; Maxime P. Vallée [France] ; Graham Byrnes [France] ; Breast Cancer Family Registry [Australie, Canada, États-Unis] ; John L. Hopper [Australie] ; Melissa C. Southey [Australie] ; Irene L. Andrulis [Canada] ; Esther M. John [États-Unis] ; Sean V. Tavtigian [États-Unis] ; Fabienne Lesueur [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
Although inherited breast cancer has been associated with germline mutations in genes that are functionally involved in the DNA homologous recombination repair (HRR) pathway, including
We screened the coding exons and proximal splice junction regions of the gene for germline sequence variation in 1,330 early-onset breast cancer cases and 1,123 controls from the Breast Cancer Family Registry, using the same population-based sampling and analytical strategy that we developed for assessment of rare sequence variants in
Altogether, our data suggest that
Url:
DOI: 10.1371/journal.pone.0052374
PubMed: 23300655
PubMed Central: 3531476
Affiliations:
- Australie, Canada, France, États-Unis
- Auvergne-Rhône-Alpes, Californie, Rhône-Alpes, Utah, Victoria (État)
- Lyon, Melbourne
- Université de Melbourne
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002A55
- to stream Pmc, to step Curation: 002905
- to stream Pmc, to step Checkpoint: 002101
- to stream Ncbi, to step Merge: 001088
- to stream Ncbi, to step Curation: 001088
- to stream Ncbi, to step Checkpoint: 001088
- to stream Main, to step Merge: 005772
- to stream Main, to step Curation: 005506
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>RAD51</italic>
and Breast Cancer Susceptibility: No Evidence for Rare Variant Association in the Breast Cancer Family Registry Study</title>
<author><name sortKey="Le Calvez Kelm, Florence" sort="Le Calvez Kelm, Florence" uniqKey="Le Calvez Kelm F" first="Florence" last="Le Calvez-Kelm">Florence Le Calvez-Kelm</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oliver, Javier" sort="Oliver, Javier" uniqKey="Oliver J" first="Javier" last="Oliver">Javier Oliver</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Damiola, Francesca" sort="Damiola, Francesca" uniqKey="Damiola F" first="Francesca" last="Damiola">Francesca Damiola</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Forey, Nathalie" sort="Forey, Nathalie" uniqKey="Forey N" first="Nathalie" last="Forey">Nathalie Forey</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Robinot, Nivonirina" sort="Robinot, Nivonirina" uniqKey="Robinot N" first="Nivonirina" last="Robinot">Nivonirina Robinot</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Durand, Geoffroy" sort="Durand, Geoffroy" uniqKey="Durand G" first="Geoffroy" last="Durand">Geoffroy Durand</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Voegele, Catherine" sort="Voegele, Catherine" uniqKey="Voegele C" first="Catherine" last="Voegele">Catherine Voegele</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vallee, Maxime P" sort="Vallee, Maxime P" uniqKey="Vallee M" first="Maxime P." last="Vallée">Maxime P. Vallée</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Byrnes, Graham" sort="Byrnes, Graham" uniqKey="Byrnes G" first="Graham" last="Byrnes">Graham Byrnes</name>
<affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Biostatistics Group, International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Biostatistics Group, International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Registry, Breast Cancer Family" sort="Registry, Breast Cancer Family" uniqKey="Registry B" first="Breast Cancer Family" last="Registry">Breast Cancer Family Registry</name>
<affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Center for Molecular, Environmental, Genetic and Analytical Epidemiology, School of Population Health, EGA The University of Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Center for Molecular, Environmental, Genetic and Analytical Epidemiology, School of Population Health, EGA The University of Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff4"><addr-line>Genetic Epidemiology Laboratory, The University of Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology Laboratory, The University of Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Department of Molecular Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Molecular Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Cancer Prevention Institute of California, Fremont, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cancer Prevention Institute of California, Fremont, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Stanford University School of Medicine and Stanford Cancer Institute, Stanford, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford University School of Medicine and Stanford Cancer Institute, Stanford, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Center for Molecular, Environmental, Genetic and Analytical Epidemiology, School of Population Health, EGA The University of Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Center for Molecular, Environmental, Genetic and Analytical Epidemiology, School of Population Health, EGA The University of Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name>
<affiliation wicri:level="4"><nlm:aff id="aff4"><addr-line>Genetic Epidemiology Laboratory, The University of Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology Laboratory, The University of Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Department of Molecular Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Molecular Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name>
<affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Cancer Prevention Institute of California, Fremont, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cancer Prevention Institute of California, Fremont, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Stanford University School of Medicine and Stanford Cancer Institute, Stanford, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford University School of Medicine and Stanford Cancer Institute, Stanford, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tavtigian, Sean V" sort="Tavtigian, Sean V" uniqKey="Tavtigian S" first="Sean V." last="Tavtigian">Sean V. Tavtigian</name>
<affiliation wicri:level="2"><nlm:aff id="aff8"><addr-line>Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah</wicri:regionArea>
<placeName><region type="state">Utah</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lesueur, Fabienne" sort="Lesueur, Fabienne" uniqKey="Lesueur F" first="Fabienne" last="Lesueur">Fabienne Lesueur</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23300655</idno>
<idno type="pmc">3531476</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531476</idno>
<idno type="RBID">PMC:3531476</idno>
<idno type="doi">10.1371/journal.pone.0052374</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">002A55</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002A55</idno>
<idno type="wicri:Area/Pmc/Curation">002905</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002905</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002101</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002101</idno>
<idno type="wicri:Area/Ncbi/Merge">001088</idno>
<idno type="wicri:Area/Ncbi/Curation">001088</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001088</idno>
<idno type="wicri:Area/Main/Merge">005772</idno>
<idno type="wicri:Area/Main/Curation">005506</idno>
<idno type="wicri:Area/Main/Exploration">005506</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>RAD51</italic>
and Breast Cancer Susceptibility: No Evidence for Rare Variant Association in the Breast Cancer Family Registry Study</title>
<author><name sortKey="Le Calvez Kelm, Florence" sort="Le Calvez Kelm, Florence" uniqKey="Le Calvez Kelm F" first="Florence" last="Le Calvez-Kelm">Florence Le Calvez-Kelm</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oliver, Javier" sort="Oliver, Javier" uniqKey="Oliver J" first="Javier" last="Oliver">Javier Oliver</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Damiola, Francesca" sort="Damiola, Francesca" uniqKey="Damiola F" first="Francesca" last="Damiola">Francesca Damiola</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Forey, Nathalie" sort="Forey, Nathalie" uniqKey="Forey N" first="Nathalie" last="Forey">Nathalie Forey</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Robinot, Nivonirina" sort="Robinot, Nivonirina" uniqKey="Robinot N" first="Nivonirina" last="Robinot">Nivonirina Robinot</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Durand, Geoffroy" sort="Durand, Geoffroy" uniqKey="Durand G" first="Geoffroy" last="Durand">Geoffroy Durand</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Voegele, Catherine" sort="Voegele, Catherine" uniqKey="Voegele C" first="Catherine" last="Voegele">Catherine Voegele</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vallee, Maxime P" sort="Vallee, Maxime P" uniqKey="Vallee M" first="Maxime P." last="Vallée">Maxime P. Vallée</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Byrnes, Graham" sort="Byrnes, Graham" uniqKey="Byrnes G" first="Graham" last="Byrnes">Graham Byrnes</name>
<affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Biostatistics Group, International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Biostatistics Group, International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Registry, Breast Cancer Family" sort="Registry, Breast Cancer Family" uniqKey="Registry B" first="Breast Cancer Family" last="Registry">Breast Cancer Family Registry</name>
<affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Center for Molecular, Environmental, Genetic and Analytical Epidemiology, School of Population Health, EGA The University of Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Center for Molecular, Environmental, Genetic and Analytical Epidemiology, School of Population Health, EGA The University of Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff4"><addr-line>Genetic Epidemiology Laboratory, The University of Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology Laboratory, The University of Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Department of Molecular Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Molecular Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Cancer Prevention Institute of California, Fremont, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cancer Prevention Institute of California, Fremont, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Stanford University School of Medicine and Stanford Cancer Institute, Stanford, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford University School of Medicine and Stanford Cancer Institute, Stanford, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Center for Molecular, Environmental, Genetic and Analytical Epidemiology, School of Population Health, EGA The University of Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Center for Molecular, Environmental, Genetic and Analytical Epidemiology, School of Population Health, EGA The University of Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name>
<affiliation wicri:level="4"><nlm:aff id="aff4"><addr-line>Genetic Epidemiology Laboratory, The University of Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology Laboratory, The University of Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Department of Molecular Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Molecular Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name>
<affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Cancer Prevention Institute of California, Fremont, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cancer Prevention Institute of California, Fremont, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Stanford University School of Medicine and Stanford Cancer Institute, Stanford, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford University School of Medicine and Stanford Cancer Institute, Stanford, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tavtigian, Sean V" sort="Tavtigian, Sean V" uniqKey="Tavtigian S" first="Sean V." last="Tavtigian">Sean V. Tavtigian</name>
<affiliation wicri:level="2"><nlm:aff id="aff8"><addr-line>Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah</wicri:regionArea>
<placeName><region type="state">Utah</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lesueur, Fabienne" sort="Lesueur, Fabienne" uniqKey="Lesueur F" first="Fabienne" last="Lesueur">Fabienne Lesueur</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Although inherited breast cancer has been associated with germline mutations in genes that are functionally involved in the DNA homologous recombination repair (HRR) pathway, including <italic>BRCA1</italic>
, <italic>BRCA2</italic>
, <italic>TP53</italic>
, <italic>ATM</italic>
, <italic>BRIP1</italic>
, <italic>CHEK2</italic>
and <italic>PALB2,</italic>
about 70% of breast cancer heritability remains unexplained. Because of their critical functions in maintaining genome integrity and already well-established associations with breast cancer susceptibility, it is likely that additional genes involved in the HRR pathway harbor sequence variants associated with increased risk of breast cancer. <italic>RAD51</italic>
plays a central biological function in DNA repair and despite the fact that rare, likely dysfunctional variants in three of its five paralogs, <italic>RAD51C, RAD51D,</italic>
and <italic>XRCC2,</italic>
have been associated with breast and/or ovarian cancer risk, no population-based case-control mutation screening data are available for the <italic>RAD51</italic>
gene. We thus postulated that <italic>RAD51</italic>
could harbor rare germline mutations that confer increased risk of breast cancer.</p>
</sec>
<sec><title>Methodology/Principal Findings</title>
<p>We screened the coding exons and proximal splice junction regions of the gene for germline sequence variation in 1,330 early-onset breast cancer cases and 1,123 controls from the Breast Cancer Family Registry, using the same population-based sampling and analytical strategy that we developed for assessment of rare sequence variants in <italic>ATM</italic>
and <italic>CHEK2.</italic>
In total, 12 distinct very rare or private variants were characterized in <italic>RAD51</italic>
, with 10 cases (0.75%) and 9 controls (0.80%) carrying such a variant. Variants were either likely neutral missense substitutions (3), silent substitutions (4) or non-coding substitutions (5) that were predicted to have little effect on efficiency of the splicing machinery.</p>
</sec>
<sec><title>Conclusion</title>
<p>Altogether, our data suggest that <italic>RAD51</italic>
tolerates so little dysfunctional sequence variation that rare variants in the gene contribute little, if anything, to breast cancer susceptibility.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Khanna, Kk" uniqKey="Khanna K">KK Khanna</name>
</author>
<author><name sortKey="Jackson, Sp" uniqKey="Jackson S">SP Jackson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ford, D" uniqKey="Ford D">D Ford</name>
</author>
<author><name sortKey="Easton, Df" uniqKey="Easton D">DF Easton</name>
</author>
<author><name sortKey="Bishop, Dt" uniqKey="Bishop D">DT Bishop</name>
</author>
<author><name sortKey="Narod, Sa" uniqKey="Narod S">SA Narod</name>
</author>
<author><name sortKey="Goldgar, De" uniqKey="Goldgar D">DE Goldgar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ford, D" uniqKey="Ford D">D Ford</name>
</author>
<author><name sortKey="Easton, Df" uniqKey="Easton D">DF Easton</name>
</author>
<author><name sortKey="Stratton, M" uniqKey="Stratton M">M Stratton</name>
</author>
<author><name sortKey="Narod, S" uniqKey="Narod S">S Narod</name>
</author>
<author><name sortKey="Goldgar, D" uniqKey="Goldgar D">D Goldgar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Couch, Fj" uniqKey="Couch F">FJ Couch</name>
</author>
<author><name sortKey="Farid, Lm" uniqKey="Farid L">LM Farid</name>
</author>
<author><name sortKey="Deshano, Ml" uniqKey="Deshano M">ML DeShano</name>
</author>
<author><name sortKey="Tavtigian, Sv" uniqKey="Tavtigian S">SV Tavtigian</name>
</author>
<author><name sortKey="Calzone, K" uniqKey="Calzone K">K Calzone</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Malkin, D" uniqKey="Malkin D">D Malkin</name>
</author>
<author><name sortKey="Li, Fp" uniqKey="Li F">FP Li</name>
</author>
<author><name sortKey="Strong, Lc" uniqKey="Strong L">LC Strong</name>
</author>
<author><name sortKey="Fraumeni, Jf" uniqKey="Fraumeni J">JF Fraumeni</name>
</author>
<author><name sortKey="Nelson, Ce" uniqKey="Nelson C">CE Nelson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Renwick, A" uniqKey="Renwick A">A Renwick</name>
</author>
<author><name sortKey="Thompson, D" uniqKey="Thompson D">D Thompson</name>
</author>
<author><name sortKey="Seal, S" uniqKey="Seal S">S Seal</name>
</author>
<author><name sortKey="Kelly, P" uniqKey="Kelly P">P Kelly</name>
</author>
<author><name sortKey="Chagtai, T" uniqKey="Chagtai T">T Chagtai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tavtigian, Sv" uniqKey="Tavtigian S">SV Tavtigian</name>
</author>
<author><name sortKey="Oefner, Pj" uniqKey="Oefner P">PJ Oefner</name>
</author>
<author><name sortKey="Babikyan, D" uniqKey="Babikyan D">D Babikyan</name>
</author>
<author><name sortKey="Hartmann, A" uniqKey="Hartmann A">A Hartmann</name>
</author>
<author><name sortKey="Healey, S" uniqKey="Healey S">S Healey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Goldgar, De" uniqKey="Goldgar D">DE Goldgar</name>
</author>
<author><name sortKey="Healey, S" uniqKey="Healey S">S Healey</name>
</author>
<author><name sortKey="Dowty, Jg" uniqKey="Dowty J">JG Dowty</name>
</author>
<author><name sortKey="Da Silva, L" uniqKey="Da Silva L">L Da Silva</name>
</author>
<author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seal, S" uniqKey="Seal S">S Seal</name>
</author>
<author><name sortKey="Thompson, D" uniqKey="Thompson D">D Thompson</name>
</author>
<author><name sortKey="Renwick, A" uniqKey="Renwick A">A Renwick</name>
</author>
<author><name sortKey="Elliott, A" uniqKey="Elliott A">A Elliott</name>
</author>
<author><name sortKey="Kelly, P" uniqKey="Kelly P">P Kelly</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meijers Heijboer, H" uniqKey="Meijers Heijboer H">H Meijers-Heijboer</name>
</author>
<author><name sortKey="Van Den Ouweland, A" uniqKey="Van Den Ouweland A">A van den Ouweland</name>
</author>
<author><name sortKey="Klijn, J" uniqKey="Klijn J">J Klijn</name>
</author>
<author><name sortKey="Wasielewski, M" uniqKey="Wasielewski M">M Wasielewski</name>
</author>
<author><name sortKey="De Snoo, A" uniqKey="De Snoo A">A de Snoo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Le Calvez Kelm, F" uniqKey="Le Calvez Kelm F">F Le Calvez-Kelm</name>
</author>
<author><name sortKey="Lesueur, F" uniqKey="Lesueur F">F Lesueur</name>
</author>
<author><name sortKey="Damiola, F" uniqKey="Damiola F">F Damiola</name>
</author>
<author><name sortKey="Vallee, M" uniqKey="Vallee M">M Vallee</name>
</author>
<author><name sortKey="Voegele, C" uniqKey="Voegele C">C Voegele</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rahman, N" uniqKey="Rahman N">N Rahman</name>
</author>
<author><name sortKey="Seal, S" uniqKey="Seal S">S Seal</name>
</author>
<author><name sortKey="Thompson, D" uniqKey="Thompson D">D Thompson</name>
</author>
<author><name sortKey="Kelly, P" uniqKey="Kelly P">P Kelly</name>
</author>
<author><name sortKey="Renwick, A" uniqKey="Renwick A">A Renwick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Erkko, H" uniqKey="Erkko H">H Erkko</name>
</author>
<author><name sortKey="Dowty, Jg" uniqKey="Dowty J">JG Dowty</name>
</author>
<author><name sortKey="Nikkila, J" uniqKey="Nikkila J">J Nikkila</name>
</author>
<author><name sortKey="Syrjakoski, K" uniqKey="Syrjakoski K">K Syrjakoski</name>
</author>
<author><name sortKey="Mannermaa, A" uniqKey="Mannermaa A">A Mannermaa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Southey, Mc" uniqKey="Southey M">MC Southey</name>
</author>
<author><name sortKey="Teo, Zl" uniqKey="Teo Z">ZL Teo</name>
</author>
<author><name sortKey="Dowty, Jg" uniqKey="Dowty J">JG Dowty</name>
</author>
<author><name sortKey="Odefrey, Fa" uniqKey="Odefrey F">FA Odefrey</name>
</author>
<author><name sortKey="Park, Dj" uniqKey="Park D">DJ Park</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Park, Dj" uniqKey="Park D">DJ Park</name>
</author>
<author><name sortKey="Lesueur, F" uniqKey="Lesueur F">F Lesueur</name>
</author>
<author><name sortKey="Nguyen Dumont, T" uniqKey="Nguyen Dumont T">T Nguyen-Dumont</name>
</author>
<author><name sortKey="Pertesi, M" uniqKey="Pertesi M">M Pertesi</name>
</author>
<author><name sortKey="Odefrey, F" uniqKey="Odefrey F">F Odefrey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="West, Sc" uniqKey="West S">SC West</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sturzbecher, Hw" uniqKey="Sturzbecher H">HW Sturzbecher</name>
</author>
<author><name sortKey="Donzelmann, B" uniqKey="Donzelmann B">B Donzelmann</name>
</author>
<author><name sortKey="Henning, W" uniqKey="Henning W">W Henning</name>
</author>
<author><name sortKey="Knippschild, U" uniqKey="Knippschild U">U Knippschild</name>
</author>
<author><name sortKey="Buchhop, S" uniqKey="Buchhop S">S Buchhop</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Scully, R" uniqKey="Scully R">R Scully</name>
</author>
<author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name>
</author>
<author><name sortKey="Plug, A" uniqKey="Plug A">A Plug</name>
</author>
<author><name sortKey="Xiao, Y" uniqKey="Xiao Y">Y Xiao</name>
</author>
<author><name sortKey="Weaver, D" uniqKey="Weaver D">D Weaver</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wong, Ak" uniqKey="Wong A">AK Wong</name>
</author>
<author><name sortKey="Pero, R" uniqKey="Pero R">R Pero</name>
</author>
<author><name sortKey="Ormonde, Pa" uniqKey="Ormonde P">PA Ormonde</name>
</author>
<author><name sortKey="Tavtigian, Sv" uniqKey="Tavtigian S">SV Tavtigian</name>
</author>
<author><name sortKey="Bartel, Pl" uniqKey="Bartel P">PL Bartel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dray, E" uniqKey="Dray E">E Dray</name>
</author>
<author><name sortKey="Etchin, J" uniqKey="Etchin J">J Etchin</name>
</author>
<author><name sortKey="Wiese, C" uniqKey="Wiese C">C Wiese</name>
</author>
<author><name sortKey="Saro, D" uniqKey="Saro D">D Saro</name>
</author>
<author><name sortKey="Williams, Gj" uniqKey="Williams G">GJ Williams</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maacke, H" uniqKey="Maacke H">H Maacke</name>
</author>
<author><name sortKey="Opitz, S" uniqKey="Opitz S">S Opitz</name>
</author>
<author><name sortKey="Jost, K" uniqKey="Jost K">K Jost</name>
</author>
<author><name sortKey="Hamdorf, W" uniqKey="Hamdorf W">W Hamdorf</name>
</author>
<author><name sortKey="Henning, W" uniqKey="Henning W">W Henning</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yoshikawa, K" uniqKey="Yoshikawa K">K Yoshikawa</name>
</author>
<author><name sortKey="Ogawa, T" uniqKey="Ogawa T">T Ogawa</name>
</author>
<author><name sortKey="Baer, R" uniqKey="Baer R">R Baer</name>
</author>
<author><name sortKey="Hemmi, H" uniqKey="Hemmi H">H Hemmi</name>
</author>
<author><name sortKey="Honda, K" uniqKey="Honda K">K Honda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Levy Lahad, E" uniqKey="Levy Lahad E">E Levy-Lahad</name>
</author>
<author><name sortKey="Lahad, A" uniqKey="Lahad A">A Lahad</name>
</author>
<author><name sortKey="Eisenberg, S" uniqKey="Eisenberg S">S Eisenberg</name>
</author>
<author><name sortKey="Dagan, E" uniqKey="Dagan E">E Dagan</name>
</author>
<author><name sortKey="Paperna, T" uniqKey="Paperna T">T Paperna</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kadouri, L" uniqKey="Kadouri L">L Kadouri</name>
</author>
<author><name sortKey="Kote Jarai, Z" uniqKey="Kote Jarai Z">Z Kote-Jarai</name>
</author>
<author><name sortKey="Hubert, A" uniqKey="Hubert A">A Hubert</name>
</author>
<author><name sortKey="Durocher, F" uniqKey="Durocher F">F Durocher</name>
</author>
<author><name sortKey="Abeliovich, D" uniqKey="Abeliovich D">D Abeliovich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Antoniou, Ac" uniqKey="Antoniou A">AC Antoniou</name>
</author>
<author><name sortKey="Sinilnikova, Om" uniqKey="Sinilnikova O">OM Sinilnikova</name>
</author>
<author><name sortKey="Simard, J" uniqKey="Simard J">J Simard</name>
</author>
<author><name sortKey="Leone, M" uniqKey="Leone M">M Leone</name>
</author>
<author><name sortKey="Dumont, M" uniqKey="Dumont M">M Dumont</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gao, Lb" uniqKey="Gao L">LB Gao</name>
</author>
<author><name sortKey="Pan, Xm" uniqKey="Pan X">XM Pan</name>
</author>
<author><name sortKey="Li, Lj" uniqKey="Li L">LJ Li</name>
</author>
<author><name sortKey="Liang, Wb" uniqKey="Liang W">WB Liang</name>
</author>
<author><name sortKey="Zhu, Y" uniqKey="Zhu Y">Y Zhu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, H" uniqKey="Sun H">H Sun</name>
</author>
<author><name sortKey="Bai, J" uniqKey="Bai J">J Bai</name>
</author>
<author><name sortKey="Chen, F" uniqKey="Chen F">F Chen</name>
</author>
<author><name sortKey="Jin, Y" uniqKey="Jin Y">Y Jin</name>
</author>
<author><name sortKey="Yu, Y" uniqKey="Yu Y">Y Yu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
</author>
<author><name sortKey="Dong, H" uniqKey="Dong H">H Dong</name>
</author>
<author><name sortKey="Fu, Y" uniqKey="Fu Y">Y Fu</name>
</author>
<author><name sortKey="Ding, H" uniqKey="Ding H">H Ding</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, Kd" uniqKey="Yu K">KD Yu</name>
</author>
<author><name sortKey="Yang, C" uniqKey="Yang C">C Yang</name>
</author>
<author><name sortKey="Fan, L" uniqKey="Fan L">L Fan</name>
</author>
<author><name sortKey="Chen, Ax" uniqKey="Chen A">AX Chen</name>
</author>
<author><name sortKey="Shao, Zm" uniqKey="Shao Z">ZM Shao</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Kato, M" uniqKey="Kato M">M Kato</name>
</author>
<author><name sortKey="Yano, K" uniqKey="Yano K">K Yano</name>
</author>
<author><name sortKey="Matsuo, F" uniqKey="Matsuo F">F Matsuo</name>
</author>
<author><name sortKey="Saito, H" uniqKey="Saito H">H Saito</name>
</author>
<author><name sortKey="Katagiri, T" uniqKey="Katagiri T">T Katagiri</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rapakko, K" uniqKey="Rapakko K">K Rapakko</name>
</author>
<author><name sortKey="Heikkinen, K" uniqKey="Heikkinen K">K Heikkinen</name>
</author>
<author><name sortKey="Karppinen, Sm" uniqKey="Karppinen S">SM Karppinen</name>
</author>
<author><name sortKey="Winqvist, R" uniqKey="Winqvist R">R Winqvist</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lose, F" uniqKey="Lose F">F Lose</name>
</author>
<author><name sortKey="Lovelock, P" uniqKey="Lovelock P">P Lovelock</name>
</author>
<author><name sortKey="Chenevix Trench, G" uniqKey="Chenevix Trench G">G Chenevix-Trench</name>
</author>
<author><name sortKey="Mann, Gj" uniqKey="Mann G">GJ Mann</name>
</author>
<author><name sortKey="Pupo, Gm" uniqKey="Pupo G">GM Pupo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ishida, T" uniqKey="Ishida T">T Ishida</name>
</author>
<author><name sortKey="Takizawa, Y" uniqKey="Takizawa Y">Y Takizawa</name>
</author>
<author><name sortKey="Sakane, I" uniqKey="Sakane I">I Sakane</name>
</author>
<author><name sortKey="Kurumizaka, H" uniqKey="Kurumizaka H">H Kurumizaka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tavtigian, Sv" uniqKey="Tavtigian S">SV Tavtigian</name>
</author>
<author><name sortKey="Greenblatt, Ms" uniqKey="Greenblatt M">MS Greenblatt</name>
</author>
<author><name sortKey="Lesueur, F" uniqKey="Lesueur F">F Lesueur</name>
</author>
<author><name sortKey="Byrnes, Gb" uniqKey="Byrnes G">GB Byrnes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reese, Mg" uniqKey="Reese M">MG Reese</name>
</author>
<author><name sortKey="Eeckman, Fh" uniqKey="Eeckman F">FH Eeckman</name>
</author>
<author><name sortKey="Kulp, D" uniqKey="Kulp D">D Kulp</name>
</author>
<author><name sortKey="Haussler, D" uniqKey="Haussler D">D Haussler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yeo, G" uniqKey="Yeo G">G Yeo</name>
</author>
<author><name sortKey="Burge, Cb" uniqKey="Burge C">CB Burge</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meindl, A" uniqKey="Meindl A">A Meindl</name>
</author>
<author><name sortKey="Hellebrand, H" uniqKey="Hellebrand H">H Hellebrand</name>
</author>
<author><name sortKey="Wiek, C" uniqKey="Wiek C">C Wiek</name>
</author>
<author><name sortKey="Erven, V" uniqKey="Erven V">V Erven</name>
</author>
<author><name sortKey="Wappenschmidt, B" uniqKey="Wappenschmidt B">B Wappenschmidt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Akbari, Mr" uniqKey="Akbari M">MR Akbari</name>
</author>
<author><name sortKey="Tonin, P" uniqKey="Tonin P">P Tonin</name>
</author>
<author><name sortKey="Foulkes, Wd" uniqKey="Foulkes W">WD Foulkes</name>
</author>
<author><name sortKey="Ghadirian, P" uniqKey="Ghadirian P">P Ghadirian</name>
</author>
<author><name sortKey="Tischkowitz, M" uniqKey="Tischkowitz M">M Tischkowitz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zheng, Y" uniqKey="Zheng Y">Y Zheng</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name>
</author>
<author><name sortKey="Hope, K" uniqKey="Hope K">K Hope</name>
</author>
<author><name sortKey="Niu, Q" uniqKey="Niu Q">Q Niu</name>
</author>
<author><name sortKey="Huo, D" uniqKey="Huo D">D Huo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Loveday, C" uniqKey="Loveday C">C Loveday</name>
</author>
<author><name sortKey="Turnbull, C" uniqKey="Turnbull C">C Turnbull</name>
</author>
<author><name sortKey="Ramsay, E" uniqKey="Ramsay E">E Ramsay</name>
</author>
<author><name sortKey="Hughes, D" uniqKey="Hughes D">D Hughes</name>
</author>
<author><name sortKey="Ruark, E" uniqKey="Ruark E">E Ruark</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lim, Ds" uniqKey="Lim D">DS Lim</name>
</author>
<author><name sortKey="Hasty, P" uniqKey="Hasty P">P Hasty</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tsuzuki, T" uniqKey="Tsuzuki T">T Tsuzuki</name>
</author>
<author><name sortKey="Fujii, Y" uniqKey="Fujii Y">Y Fujii</name>
</author>
<author><name sortKey="Sakumi, K" uniqKey="Sakumi K">K Sakumi</name>
</author>
<author><name sortKey="Tominaga, Y" uniqKey="Tominaga Y">Y Tominaga</name>
</author>
<author><name sortKey="Nakao, K" uniqKey="Nakao K">K Nakao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Pl" uniqKey="Chen P">PL Chen</name>
</author>
<author><name sortKey="Chen, Cf" uniqKey="Chen C">CF Chen</name>
</author>
<author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name>
</author>
<author><name sortKey="Xiao, J" uniqKey="Xiao J">J Xiao</name>
</author>
<author><name sortKey="Sharp, Zd" uniqKey="Sharp Z">ZD Sharp</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pellegrini, L" uniqKey="Pellegrini L">L Pellegrini</name>
</author>
<author><name sortKey="Yu, Ds" uniqKey="Yu D">DS Yu</name>
</author>
<author><name sortKey="Lo, T" uniqKey="Lo T">T Lo</name>
</author>
<author><name sortKey="Anand, S" uniqKey="Anand S">S Anand</name>
</author>
<author><name sortKey="Lee, M" uniqKey="Lee M">M Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Park, Jy" uniqKey="Park J">JY Park</name>
</author>
<author><name sortKey="Yoo, Hw" uniqKey="Yoo H">HW Yoo</name>
</author>
<author><name sortKey="Kim, Br" uniqKey="Kim B">BR Kim</name>
</author>
<author><name sortKey="Park, R" uniqKey="Park R">R Park</name>
</author>
<author><name sortKey="Choi, Sy" uniqKey="Choi S">SY Choi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shin, Ds" uniqKey="Shin D">DS Shin</name>
</author>
<author><name sortKey="Pellegrini, L" uniqKey="Pellegrini L">L Pellegrini</name>
</author>
<author><name sortKey="Daniels, Ds" uniqKey="Daniels D">DS Daniels</name>
</author>
<author><name sortKey="Yelent, B" uniqKey="Yelent B">B Yelent</name>
</author>
<author><name sortKey="Craig, L" uniqKey="Craig L">L Craig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="John, Em" uniqKey="John E">EM John</name>
</author>
<author><name sortKey="Hopper, Jl" uniqKey="Hopper J">JL Hopper</name>
</author>
<author><name sortKey="Beck, Jc" uniqKey="Beck J">JC Beck</name>
</author>
<author><name sortKey="Knight, Ja" uniqKey="Knight J">JA Knight</name>
</author>
<author><name sortKey="Neuhausen, Sl" uniqKey="Neuhausen S">SL Neuhausen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Voegele, C" uniqKey="Voegele C">C Voegele</name>
</author>
<author><name sortKey="Tavtigian, Sv" uniqKey="Tavtigian S">SV Tavtigian</name>
</author>
<author><name sortKey="De Silva, D" uniqKey="De Silva D">D de Silva</name>
</author>
<author><name sortKey="Cuber, S" uniqKey="Cuber S">S Cuber</name>
</author>
<author><name sortKey="Thomas, A" uniqKey="Thomas A">A Thomas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nguyen Dumont, T" uniqKey="Nguyen Dumont T">T Nguyen-Dumont</name>
</author>
<author><name sortKey="Calvez Kelm, Fl" uniqKey="Calvez Kelm F">FL Calvez-Kelm</name>
</author>
<author><name sortKey="Forey, N" uniqKey="Forey N">N Forey</name>
</author>
<author><name sortKey="Mckay Chopin, S" uniqKey="Mckay Chopin S">S McKay-Chopin</name>
</author>
<author><name sortKey="Garritano, S" uniqKey="Garritano S">S Garritano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garritano, S" uniqKey="Garritano S">S Garritano</name>
</author>
<author><name sortKey="Gemignani, F" uniqKey="Gemignani F">F Gemignani</name>
</author>
<author><name sortKey="Voegele, C" uniqKey="Voegele C">C Voegele</name>
</author>
<author><name sortKey="Nguyen Dumont, T" uniqKey="Nguyen Dumont T">T Nguyen-Dumont</name>
</author>
<author><name sortKey="Le Calvez Kelm, F" uniqKey="Le Calvez Kelm F">F Le Calvez-Kelm</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Altschul, Sf" uniqKey="Altschul S">SF Altschul</name>
</author>
<author><name sortKey="Gish, W" uniqKey="Gish W">W Gish</name>
</author>
<author><name sortKey="Miller, W" uniqKey="Miller W">W Miller</name>
</author>
<author><name sortKey="Myers, Ew" uniqKey="Myers E">EW Myers</name>
</author>
<author><name sortKey="Lipman, Dj" uniqKey="Lipman D">DJ Lipman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wallace, Im" uniqKey="Wallace I">IM Wallace</name>
</author>
<author><name sortKey="O Ullivan, O" uniqKey="O Ullivan O">O O’Sullivan</name>
</author>
<author><name sortKey="Higgins, Dg" uniqKey="Higgins D">DG Higgins</name>
</author>
<author><name sortKey="Notredame, C" uniqKey="Notredame C">C Notredame</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Felsenstein, J" uniqKey="Felsenstein J">J Felsenstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ng, Pc" uniqKey="Ng P">PC Ng</name>
</author>
<author><name sortKey="Henikoff, S" uniqKey="Henikoff S">S Henikoff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Adzhubei, Ia" uniqKey="Adzhubei I">IA Adzhubei</name>
</author>
<author><name sortKey="Schmidt, S" uniqKey="Schmidt S">S Schmidt</name>
</author>
<author><name sortKey="Peshkin, L" uniqKey="Peshkin L">L Peshkin</name>
</author>
<author><name sortKey="Ramensky, Ve" uniqKey="Ramensky V">VE Ramensky</name>
</author>
<author><name sortKey="Gerasimova, A" uniqKey="Gerasimova A">A Gerasimova</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Canada</li>
<li>France</li>
<li>États-Unis</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Californie</li>
<li>Rhône-Alpes</li>
<li>Utah</li>
<li>Victoria (État)</li>
</region>
<settlement><li>Lyon</li>
<li>Melbourne</li>
</settlement>
<orgName><li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Le Calvez Kelm, Florence" sort="Le Calvez Kelm, Florence" uniqKey="Le Calvez Kelm F" first="Florence" last="Le Calvez-Kelm">Florence Le Calvez-Kelm</name>
</region>
<name sortKey="Byrnes, Graham" sort="Byrnes, Graham" uniqKey="Byrnes G" first="Graham" last="Byrnes">Graham Byrnes</name>
<name sortKey="Damiola, Francesca" sort="Damiola, Francesca" uniqKey="Damiola F" first="Francesca" last="Damiola">Francesca Damiola</name>
<name sortKey="Durand, Geoffroy" sort="Durand, Geoffroy" uniqKey="Durand G" first="Geoffroy" last="Durand">Geoffroy Durand</name>
<name sortKey="Forey, Nathalie" sort="Forey, Nathalie" uniqKey="Forey N" first="Nathalie" last="Forey">Nathalie Forey</name>
<name sortKey="Lesueur, Fabienne" sort="Lesueur, Fabienne" uniqKey="Lesueur F" first="Fabienne" last="Lesueur">Fabienne Lesueur</name>
<name sortKey="Oliver, Javier" sort="Oliver, Javier" uniqKey="Oliver J" first="Javier" last="Oliver">Javier Oliver</name>
<name sortKey="Robinot, Nivonirina" sort="Robinot, Nivonirina" uniqKey="Robinot N" first="Nivonirina" last="Robinot">Nivonirina Robinot</name>
<name sortKey="Vallee, Maxime P" sort="Vallee, Maxime P" uniqKey="Vallee M" first="Maxime P." last="Vallée">Maxime P. Vallée</name>
<name sortKey="Voegele, Catherine" sort="Voegele, Catherine" uniqKey="Voegele C" first="Catherine" last="Voegele">Catherine Voegele</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Registry, Breast Cancer Family" sort="Registry, Breast Cancer Family" uniqKey="Registry B" first="Breast Cancer Family" last="Registry">Breast Cancer Family Registry</name>
</region>
<name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<name sortKey="Registry, Breast Cancer Family" sort="Registry, Breast Cancer Family" uniqKey="Registry B" first="Breast Cancer Family" last="Registry">Breast Cancer Family Registry</name>
<name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name>
</country>
<country name="Canada"><noRegion><name sortKey="Registry, Breast Cancer Family" sort="Registry, Breast Cancer Family" uniqKey="Registry B" first="Breast Cancer Family" last="Registry">Breast Cancer Family Registry</name>
</noRegion>
<name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name>
</country>
<country name="États-Unis"><region name="Californie"><name sortKey="Registry, Breast Cancer Family" sort="Registry, Breast Cancer Family" uniqKey="Registry B" first="Breast Cancer Family" last="Registry">Breast Cancer Family Registry</name>
</region>
<name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name>
<name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name>
<name sortKey="Registry, Breast Cancer Family" sort="Registry, Breast Cancer Family" uniqKey="Registry B" first="Breast Cancer Family" last="Registry">Breast Cancer Family Registry</name>
<name sortKey="Tavtigian, Sean V" sort="Tavtigian, Sean V" uniqKey="Tavtigian S" first="Sean V." last="Tavtigian">Sean V. Tavtigian</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005506 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 005506 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:3531476 |texte= RAD51 and Breast Cancer Susceptibility: No Evidence for Rare Variant Association in the Breast Cancer Family Registry Study }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23300655" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
This area was generated with Dilib version V0.6.33. |